Bayer 04 Leverkusen vs PSV: Predictions, Betting odds, Lineups, Preview

Explore Bwin's detailed preview for Bayer 04 Leverkusen vs PSV in the Champions League. Stats, odds, predictions, and lineups for the 20:00 BST match.

• Fixture: Bayer 04 Leverkusen vs PSV

• Date: Wednesday, 01 October 2025

• Kick-off: 20:00 BST

• Venue: BayArena

Match Prediction: Bayer 04 Leverkusen 2-1 PSV

Bayer 04 Leverkusen, coming off a 2-2 draw against FC København, will look to exploit their attacking prowess against a PSV side that recently lost 1-3 at home to Union Saint-Gilloise.

Leverkusen's ability to score twice away from home suggests they can challenge PSV's defence, which has shown vulnerability. The game may hinge on Leverkusen's midfield control and their capacity to convert chances into goals.

PSV, despite their recent loss, will aim to rebound with a strong performance. Their defeat at home indicates a need for defensive solidity, but their attacking line, led by players like Pepi and Saibari, could pose a threat to Leverkusen. 

The match could be closely contested, with PSV looking to capitalise on any Leverkusen errors while trying to shore up their backline.

Bayer 04 Leverkusen's recent 2-2 draw against FC København highlights their ability to score on the road, but also showcases defensive frailties. This form suggests they will be aggressive in attack, but need to tighten up at the back. 

Their performance against PSV could be influenced by their ability to maintain a high tempo and capitalise on scoring opportunities.

Recent Champions League Results:

• Draw: 2-2 vs FC København (A)

PSV's recent 1-3 loss at home to Union Saint-Gilloise indicates a dip in form, particularly in defence. This result may impact their confidence, but their attacking players remain a threat. 

Against Bayer 04 Leverkusen, PSV will need to focus on improving their defensive organisation while leveraging their forwards to challenge Leverkusen's backline.

Recent Champions League Results:

• Loss: 1-3 vs Union Saint-Gilloise (H)

Bayer 04 Leverkusen and PSV have never met in the Champions League,.

• Alejo Sarco (International Duty) - Out

• Exequiel Palacios (Groin) - Out

• Martin Terrier (Achilles) - Out

• Nathan Tella (Knee) - Doubt

• Alassane Pléa (Knee) - Out

• Myron Boadu (Hamstring) - Out

• Kiliann Sildillia (Unknown) - Out

• Predicted lineup: Flekken, Quansah, Badé, Tapsoba, Vázquez, Andrich, García, Grimaldo, Ben Seghir, Tillman, Schick

Bayer 04 Leverkusen's predicted lineup suggests a focus on midfield control with Andrich and García, aiming to dictate the tempo and create scoring opportunities for forwards like Schick and Ben Seghir.

• Predicted lineup: Kovar, Dest, Flamingo, Obispo, Gasiorowski, Veerman, Schouten, Perisic, Saibari, Van Bommel, Pepi

PSV's predicted lineup suggests a reliance on Veerman and Schouten in midfield to provide stability and support the attacking trio of Pepi, Saibari, and Perišić, who will aim to exploit any gaps in Leverkusen's defence.

• Schick vs Flamingo: This duel will see Leverkusen's forward Schick test PSV's defender with his finishing ability.

• Andrich vs Veerman: Andrich, a key midfielder for Leverkusen, will look to outmanoeuvre PSV's Veerman in the midfield battle, controlling the game's tempo.

• Ben Seghir (Bayer 04 Leverkusen): Seghir's versatility and goal-scoring threat make him a crucial player for Leverkusen, capable of turning the game in their favour.

• Veerman (PSV): Veerman's ability to control the midfield and distribute the ball effectively makes him a pivotal player for PSV, essential for their attacking transitions.

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