PSV vs Napoli: Predictions, Betting odds, Lineups, Preview

Explore Bwin's detailed preview for PSV vs Napoli in the Champions League. Stats, odds, predictions, and lineups for the 20:00 BST match.

• Fixture: PSV vs Napoli

• Date: Tuesday, 21 October 2025

• Kick-off: 20:00 BST

• Venue: Philips Stadion

Match Prediction: PSV 1-2 Napoli

PSV's recent form suggests a team struggling to find consistency, with a draw against Bayer 04 Leverkusen and a loss to Union Saint-Gilloise. Their playing style has shown vulnerability at the back, which Napoli could exploit. However, PSV's attacking threats, as seen in their games, could pose problems for Napoli's defence, particularly if they can capitalise on any lapses in concentration.

Napoli, on the other hand, have shown they can secure victories at home, as demonstrated by their win over Sporting CP. Their loss to Manchester City away from home indicates potential struggles on the road, which could be a factor in this match. Napoli's ability to control the midfield and launch quick counter-attacks might be key to overcoming PSV's defensive frailties.

PSV's recent results indicate a team in search of stability, with a draw against Bayer 04 Leverkusen and a loss to Union Saint-Gilloise. These outcomes suggest a defence that has been porous, which could be a concern against a Napoli side capable of exploiting such weaknesses.

However, PSV's attacking players have shown they can create chances, and this could be crucial if they are to challenge Napoli effectively.

Recent Champions League Results:

• Draw: 1-1 vs Bayer 04 Leverkusen (A)

• Loss: 1-3 vs Union Saint-Gilloise (H)

Napoli's form has been mixed, with a convincing home win against Sporting CP and a disappointing loss to Manchester City away. This suggests a team that performs better on home soil but struggles on the road.

Their ability to control games through midfield and launch effective counter-attacks could be pivotal in this match, especially if they can exploit PSV's defensive vulnerabilities.

Recent Champions League Results:

• Win: 2-1 vs Sporting CP (H)

• Loss: 0-2 vs Manchester City (A)

PSV and Napoli have never met in the Champions League, leaving this match as an intriguing encounter with no historical data to guide predictions. Both teams will need to rely on their current form and tactical setups to gain an advantage. This lack of precedent adds an element of unpredictability to the contest.

• Ruben van Bommel (Knee) - Out
• Alassane Pléa (Cartilage) - Doubt
• Ricardo Pepi (Strain) - Doubt
• Eus Waayers (Calf) - Doubt
• Myron Boadu (Hamstring) - Doubt
• Kiliann Sildillia (Thigh) - Doubt

• Nikita Contini (Hand) - Doubt

• Romelu Lukaku (Hamstring) - Out

• Stanislav Lobotka (Adductor) - Doubt

• Matteo Politano (Strain) - Doubt

• Alessandro Buongiorno (Adductor) - Doubt

• Vanja Milinković-Savić (Back) - Doubt

• Amir Rrahmani (Hamstring) - Doubt

• Predicted lineup: Kovar, Mauro Júnior, Gasiorowski, Obispo, Salah-Eddine, Schouten, Veerman, Man, Salibari, Perišić, Til

PSV's predicted lineup suggests a focus on maintaining possession through midfield with Schouten and Veerman aiming to feed the attacking pair of Man and Til. Their recent form indicates a need for defensive solidity, which will be crucial against Napoli's potent attack.

• Predicted lineup: Milinković-Savić (if fit), Spinazzola, Beukema, Jesus, Gutiérrez, Lobotka (if fit), Politano, Anguissa, De Bruyne, McTominay, Højlund

Napoli's predicted lineup emphasises midfield control with Lobotka and Anguissa, supported by the creative talents of De Bruyne and McTominay. Their recent performances suggest a reliance on quick transitions, which could be key in breaking down PSV's defence.

• Guus Til vs Juan Jesus: This duel pits PSV's forward Til against Napoli's defender Jesus, with Til’s work-rate and finishing tested by Jesus’ physicality and defensive awareness.

• Joey Veerman vs Frank Anguissa: PSV's midfielder Veerman will face off against Napoli's Anguissa, a battle of creativity and control in the midfield that could dictate the flow of the game.

• Jerdy Schouten (PSV): Schouten's role in PSV's midfield is crucial, providing the link between defence and attack with his passing and ball retention skills.

• Kevin De Bruyne (Napoli): De Bruyne’s ability to drive forward and deliver dangerous balls into the box makes him a key player for Napoli, capable of unlocking PSV's defence.

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Odds and market details are accurate as of the time of publication.